The 31-year-old Perez pitched in 338 games for the Indians from 2006-12, posting a 3.64 ERA.

Craig Breslow and Andrew Miller are Boston’s curent lefties in the bullpen. Franklin Morales would be a third when he comes off the disabled list in the near future.

On Thursday night at Fenway, Ortiz will stand in the batters box against Francona for the first time since they parted ways at the end of the 2011 season.

“I mean, yeah, it’s definitely going to bring memories back,” Ortiz said. “I was with Tito for eight years. He’s a good dude. He did a lot of good things. I learned a lot of things from him. It’s going to be a little weird just watching him from the other side. It is what it is, right?”

Ortiz and Francona experienced a lot of success together, winning two World Series championships together, most memorably the one in 2004 that included the comeback from 3-0 down in the best-of-seven ALCS against the Yankees.

“It was weird watching him on ESPN at the beginning until you get used to it,” Ortiz said. “So now you watch him on the other side and it will feel weird for a couple of series. At some point, it will be pretty  normal.”

Meanwhile, in another wrinkle, prospect Allen Webster has replaced Hanrahan on the roster and will start tomorrow night, with the struggling Felix Doubront spending the next two days in the bullpen.

Manager John Farrell said that his plan for now is to slot Doubront back into the rotation the next time around.

Ortiz and his wife Tiffany are filing for a divorce. The couple has been married for nearly a decade after meeting when Ortiz was in the Minor Leagues.

“There are some situations in life that work out for a period of time and at some point they don’t work out anymore and you have to move on,” Ortiz said in an interview with MLB.com and WEEI.com. “I’m moving on. She’s moving on. Hopefully everybody respects that.”

While Ortiz wanted to release the news before it leaked out, he hopes the public will respect his family’s privacy in the ensuing weeks.

The one thing Ortiz hopes nobody will do is try to look for a connection between his marriage ending and his performance on the field.

“I’m going to separate things,” Ortiz said. “Whatever is happening to me off the field is happening, but I try not to confuse that and bring that into my job. I know how to separate things. Personal life matters, and hopefully everybody respects that.”

The couple raised three children together, daughters Jessica and Alexandra, and son D’Angelo, who remains a constant presence in the Red Sox’ clubhouse.

Ortiz wanted to emphasize that the separation has been amicable, and that both sides want to move forward with their lives.

In Sunday’s win over the Astros, Ortiz went 2-for-4 with two RBIs. Over eight games, he is hitting .516 with two homers, 11 RBIs and a 1.400 OPS.

Here is a look at what Francona said to the media before today’s game.

Obviously Francona has roots in Boston, where he lived year-round for most of his eight years as Red Sox manager.

“I’m not sure you have to have roots in Boston to care about that,” Francona said. “Obviously I do, as you guys do, too. It just seems when you turn the TV on, it’s hard for everybody. Whether it’s personal or not, it seems like it gets personal. You turn on the TV and you hear left wing, right wing. I wish there were no wings. I just wish people would get along. I don’t understand it and I don’t pretend to. I hope there are people way smarter than me who are somehow, some day able to figure this out, so stuff like this doesn’t happen. It’s hard enough being an adult. You can imagine being a little kid growing up now? It’s hard. It just makes you feel bad.Can baseball help heal people during a tough time?

“I hope so. That would be terrific. If it helps anybody at all, that would be terrific. I think that is the case. Just from being there the time I was, that day is so special to people in Boston. They’re so proud of that day. You have the Marathon, the game, it’s a big deal. It’s kind of a personal day for the city of Boston, shoot, and New England. There’s no way, I don’t know how you quantify what happens. It’s unfair. I just hope maybe this game does help some people.”

How did Francona hear about the news?

“I was here at the ballpark and one of my daughters, I saw I had a bunch of missed calls, so I called her back. That’s how I knew.”

When did he realize the magnitude of it?

“I couldn’t get to anything right away. I was tied up for a while. Then I went and turned the TV on and saw right where it was. It’s personal for just about everybody. Some of those views, you can see the church my daughter got married in. It’s very unsettling, for everybody,” Francona said.

How about playing the Red Sox for the first time?

“It’s OK. Just being as honest as I can, I had a year removed. We’re not in Boston. I had mostly eight really good years. I don’t think I’d have scripted the way it ended, but sometimes it’s time to move on. I’m really happy where I’m at here. I think it’s unfair to the players for me to have a nostalgia week. Our job is to beat them, and it is them. It doesn’t take away anything, the people I’m close to there, there’s a lot of them. I like where I’m at. I think they like where they’re at. Everything’s pretty good. I do think it will be harder when we go to Boston for me.”

How does Francona think Boston will react to the recent events?

“I really don’t know. I don’t know how anybody could answer that. I imagine they’ll be very resilient. Wouldn’t surprise me at all.”

Did Francona have time to see his old buddy, Dustin Pedroia?

“I went out and saw him for a minute, me and [former Sox catcher Kevin Cash]. He didn’t get any better looking. Neither did I.

Francona on John Farrell?

“It’s hard when the season starts. You get tunnel vision. But the day he got hired, I said the glass became half full, and I still believe that. I hope for the next three days everything that could go wrong does for them. But he’s one of my best friends, not just in baseball, but in life. They got a good hire.”

The Indians come to Boston May 23-26. That should be a far more emotional time for Francona.

On Tuesday night, 11 of the 25 players on Boston’s roster played for Francona during his time in Boston. They are: Jon Lester, Clay Buchholz, Felix Doubront, Alfredo Aceves, Andrew Miller, Junichi Tazawa, Jarrod Saltalamacchia, David Ross, Daniel Nava, Dustin Pedroia and Jacoby Ellsbury. Add in three players on the DL (David Ortiz, John Lackey and Franklin Morales) and there are 14 Francona holdovers left.

Drew, who sustained a concussion on March 7, will make his debut for the Red Sox on Wednesday.

“I think just talking with him late yesterday afternoon, he felt an additional eight to 10 at-bats would be helpful,” said Red Sox manager John Farrell. “He’s starting to feel much more comfortable but he felt like two additional games, to go nine innings each day, would put him in a better position to return to us.”

Meanwhile, Iglesias was back in the lineup on Sunday after missing Saturday’s game with a bruised right forearm.

“Yeah, and even yesterday, he was available yesterday but we had planned a down day for him, day game after the night game, just trying to balance guys’ not being accustomed to the turf here, which is the same reason Napoli is DH-ing today with Daniel at first. Jose is fully ready to go,” said Farrell.

An official Minor League rehab assignment might not be too far behind. In fact, it’s starting to sound as if Ortiz could play for the Red Sox in April.

“In talking with David, I think he’d feel comfortable with 25, 30 at-bats, likely to be taken place at Pawtucket,” said Red Sox manager John Farrell. “When that rehab assignment begins remains to be seen. We’re still hopeful of a target timeframe of sometime middle to third week of April.”

Meanwhile, Stephen Drew played in an extended Spring Training for the second day in a row and will play at Double-A Portland tomorrow. Drew could play for Boston in the Fenway Park Opener on Monday.

After weeks of speculation, manager John Farrell finally made it official on Wednesday morning. Lester will be Boston’s first pitcher out of the gate for the third consecutive season.

The news was revealed just hours before Lester got ready to make his final start of Spring Training against the Miami Marlins.

“The way he was lined up, he was probably targeted all along,” said Farrell. “At the same time, we didn’t want that to be a focal point. His work that was needed and the adjustments that he’s continued to reinforce and repeat on the mound were the priorities. We felt like it was important to focus on the needs of Spring Training for every pitcher, including Jon, before we got into the rotation [order].”

In his first five starts of Grapefruit League action, Lester went 3-0 with a 0.90 ERA, looking a lot more like the pitcher who dominated in 2008-11 than the one who stumbled last year.

“He’s gotten back to a delivery that was similar to what he had in the past,” Farrell said. “I think he’s executing pitches with the consistency we saw before that made him one of the top left-handers in the game. He’s had a very strong Spring Training. “

Right-handers Clay Buchholz and Ryan Dempster will follow Lester in New York, pitching Wednesday and Thursday respectively. Left-hander Felix Doubront and righty John Lackey will round out the rotation, pitching the first two games in Toronto.

Buchholz is on tap to pitch the Home Opener on April 8 against the Orioles.

Lester was 9-14 with a 4.82 ERA in 33 starts in 2012.

“I didn’t really like what happened last year as far as me and the way I pitched,” Lester said earlier this spring. “That’s solely on me – that’s not on anyone else, that’s not on the revolving door of pitching coaches, that’s not on our manager, that’s not on anybody but myself. I want to prove that last year was a fluke and it’s not going to happen again.”

So what did Bradley do? In his first at-bat, he belted a three-run homer to left-center.

This as also Bradley’s first time starting in the same outfield as Jacoby Ellsbury and Shane Victorino. Bradley played two innings in left on Friday in Dunedin but this was his first start there since his freshman year of high school in 2005.

No decisions have been made, but the possibility seems to be growing by the day that Bradley will head North with the Red Sox and help fill the void left by David Ortiz Stephen Drew, who are all but certain to start the season on the disabled list.

“This is probably the best environment we could put him in on the road, away from our ballpark, going up against a very good pitcher. This will be a good day for him,” said Farrell.

Farrell can’t help but recall similarities to another spring he saw a top prospect win a job out of camp, helped by an injury to a key player. When Farrell was the Indians’ farm director in 2005, Grady Sizemore was optioned down to the Minors during Spring Training. However, Juan Gonzalez suffered in injury later in camp, and Sizemore broke camp with the Indians and became a star for many years, before injuries derailed him.

What does Farrell remember about Sizemore in the spring of 2005?

“That he was ready. As is the case many times, it’s out of the players’ control. But an injury opened up a spot for him.”

And that could again be happening in 2013.

Lyle Overbay, who is competing to be the backup first baseman, has an opt-out clause in his contract that he can activate on Tuesday. Outfielder Ryan Sweeny can become a free agent on Thursday. Both those players might exercise their rights to become free agents if they don’t have assurances they will make the team.

“We certainly try to communicate with everyone as respectfully and professionally as we can, as we get close to those decisions,” said Red Sox general manager Ben Cherington. “Of course, they’re not all on the same day. We’ll have plenty of conversation between now and next week. But right now, there’s baseball still to be played in Spring Training. We’ve got to keep watching.”